The purpose of this study was to improve the solubility and dissolution rate of very\r\npoor water soluble drug Nitazoxanide by solid dispersions. Solid dispersions of\r\nNitazoxanide prepared with polyethylene glycol (PEG 6000) by hot-melt method. Physical properties and dissolution behavior of solid dispersions as well as physical mixtures were determined. Nitazoxanide was evaluated for the compatibility studies with the polymer PEG 6000 at 40�°C temperature and 75% relative humidity. Evaluation of the properties of the dispersions and physical mixtures were performed using dissolution studies, Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD) and differential scanning calorimetry (DSC). In Vitro dissolution study of pure drug, solid dispersions and physical mixtures were performed after filling in the hard gelatin capsules (transparent) in phosphate buffer pH-7.5 at 37�°C. Dissolution measurements demonstrated a significantly increased dissolution rate from the solid dispersions compared to physical mixtures. From the FTIR it was cleared that there was no any interaction between drug and polymer in case of solid dispersions as well as physical mixtures. The results from DSC and XRD analysis showed the decrease in the crystallinity of the drug in solid dispersions as compared to that of physical mixtures and pure drug. \r\nKeywords: Nitazoxanide, PEG 6000, Solid dispersions, Physical mixtures, Hot-Melt method.
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